Allured Business Media, 336 Gundersen Drive, Suite A, Carol Stream, IL, 60188 USA, Figure 1. Granactive Retinoid shows up to 10x more stability than retinol in DMI especially when comparing the 50% residual content. Good to know: the trade name of HPR is Granactive Retinoid. The Granactive Retinoid 2% in Squalane is a light-weight solution and absorbs into the skin efficiently, allowing for multiple serums to be applied in your regimen. Clinical results for Granactive Retinoid, Thermal stress stability testing of Granactive Retinoid vs Retinol in dimethyl isosorbide, customerservice@cosmeticsandtoiletries.com, Local irritation and sensitisation potential assay, Skin irritation potential vs. retinol palmitate, Toleration under environmental stresses vs. retinol palmitate. The novel retinoid should be added to the oil phase of all emulsion types, with a clinical use level of 1-2%. Our patients’ results speak for themselves. Reduction of lines and wrinkles after 14-day Granactive Retinoid application, Figure 2. To interact with retinoid receptors, retinol must first be metabolized to more active forms, such as retinaldehyde and retinoic acid using several enzymatic steps. Stimulating cell proliferation and cell turnover are important for normalizing cell renewal and repair processes. These results add credence to the beneficial safety and irritation profile of Granactive Retinoid as a topical cosmetic. These processes help fill in lines and wrinkles to give a youthful appearance, while safeguarding skin from further wrinkle development. To minimize the effects due to light and air oxidation, the products were stored in low actinic glassware and under nitrogen atmosphere. The Ordinary Granactive Retinoid; Overall Rating: Texture/Feel: Thin, watery texture: Application: Super easy to apply with the dropper: Drying Time: Dries in about 10 seconds: Smell: Virtually no smell: Short Term Results: Hydrated and soft skin: Long Term Results: Helps reduce the appearance of fine lines: Ingredients: Caprylic is used to help the skin retain moisture. The effectiveness of Granactive Retinoid at filling lines and wrinkles can be seen in Image 1. The novel retinoid is unique in that it processes innate retinoic activity, binding directly with retinoid receptors without the need for metabolic breakdown to more biologically active forms. Granactive Retinoid 5% in Squalane is a water-free solution contains a 5% concentration of an advanced retinoid active complex called Granactive Retinoid that has been shown to offer better results against multiple signs of ageing than retinol without any of the irritation and drawbacks common with retinol. Dark spots and skin imperfections are reduced for a more even skin tone as a result of the retinoid’s promotion of skin cell-sloughing and a slowing effect on melanin production, which gives a brighter and more luminous appearance to skin. The Ordinary Granactive Retinoid 5% in Squalane, 1 oz (or 30 mil as the rest of the world says) for $13.90. As with all retinoids, this product should only be applied at night and used in conjunction with sunscreen to prevent extra … The two primary reasons the use of retinoids is not universal are issues surrounding irritation potential and stability. To “unsubscribe,” click the link at the bottom of any e-mail we send. The low irritation profile of Granactive Retinoid versus retinol was demonstrated on a 24 hour occlusive patch test and can be seen in Image 2. Granactive Retinoid (INCI Name: Dimethyl Isosorbide (and) Hydroxypinacolone Retinoate), is a cosmetic grade ester of all-trans retinoic acid. This cosmetic ingredient promotes cell turnover and renewal, which translates to improved skin clarity and the appearance of a healthier complexion. Results So Far : I am thrilled with the results from this Retinol. This skin care active ingredient belongs to a class of chemical compounds termed retinoids, which are natural and synthetic derivatives of Vitamin A capable of binding to retinoid receptors. The binding of retinoid receptors can enhance gene expression, which effectively turns key cellular functions on and off. So your skin prefers retinoids to acids, that's an important discovery! So when you see a percentage of granactive retinoid being quoted, be aware that you need to divide by 10 to get the actual concentration of HPR. Granactive Retinoid is dermatologically tested to offer less irritation potential than retinol, providing a gentle, safe and effective anti-aging retinoid. Granactive Retinoid 2% in Squalane (Moderate Strength, No Irritation) 2. The Ordinary Retinol 0.2% in Squalane - 30ml, Reduce The Appearances of fine Lines, of Photo Damage and of General Skin ageing 4.4 out of 5 stars 636 £8.98£8.98 (£29.93/100 ml) £9.13£9.13 Get it … When skin cell retinoid receptors are bound with retinoids, a cascade of mechanisms that benefit skin complexion are switched on. Retinol (vitamin A) is the most popular topical retinoid used to date, but its skin irritancy and instability to sunlight has limited its scope and appeal. GRANACTIVE RETINOID ADVANCES OPPORTUNITIES IN VITAMIN A SKIN CARE BIOLOGICAL PATHWAYS TO YOUTHFUL SKIN WITH GRANACTIVE RETINOID. Like all retinoids, the highly specific set of conjugated double bonds are susceptible to oxidation resulting in degradation. This cosmetic ingredient promotes cell turnover and renewal, which translates to improved skin clarity and the appearance of a healthier complexion. Moreover, the novel retinoid stimulates skin cell proliferation; restoring thickness to skin that has become thinner over time. Note: When pregnant or breastfeeding, it is recommended to avoid any skincare products containing retinoids such as formulations with Granactive Retinoid or Retinol. Description This fast absorbing, oil-like serum contains a 2% concentration of an advanced retinoid active complex called Granactive Retinoid (Hydroxypinacolone Retinoate). This water-free solution contains a 5% concentration of an advanced retinoid active complex called Granactive Retinoid that has been shown to offer better results against multiple signs of aging than retinol without any of the irritation and drawbacks common with retinol. Retinoids don’t take as much time to reach that final product, so they’re more intense than retinol. The mechanism of action of the novel retinoid is advanced compared to retinol derivatives. Retinoids are known to have positive effect on aged skin.1 The novel retinoid combats the appearance of fine lines and wrinkles for a younger appearance while increasing skin elasticity for firmer, smoother skin texture. Retinol esters are often used to lower the irritation potential and increase stability, but a tradeoff is decreased retinoid activity and benefits. As humans age, skin becomes thinner and less elastic, leading to skin with a loose, sagging, and wrinkled appearance. Irritation profile was taken after application on a 24-hour occlusive patch test. GRANACTIVE RETINOID ADVANCES OPPORTUNITIES IN VITAMIN A SKIN CARE. I've been using it nightly for 4 months now and honestly I can't say I really see a difference. Granactive Retinoid is unique in that it processes innate retinoic activity, binding directly with retinoid receptors without the need for metabolic breakdown to more biologically active forms. This water-free solution contains a 5% concentration of an advanced retinoid active complex called Granactive Retinoid that has been shown to offer better results against multiple signs of ageing than retinol without any of the irritation and drawbacks common with retinol. The binding of retinoid receptors can enhance gene expression, which effectively turns key cellular functions on and off. … Granactive Retinoid is a next-generation anti-aging product, delivering the performance of retinol and retinoid derivatives with significantly lower irritation potential, thus supporting clear, visibly more youthful looking skin with better consumer acceptance. The AHA Complex in Evening Detox is a trio of resurfacing Alpha Hydroxy Acids to deeply clean pores, help to banish breakouts and boost radiance. Both compounds show signs of decomposition by being stored under atypical conditions. However, the novel retinoid was found to have 10 times better oxidative stability than retinol in DMI in thermal stress testing (see Thermal stress stability testing of Granactive Retinoid vs Retinol in dimethyl isosorbide). 1. Retinol (Vitamin A) is the most popular topical retinoid used to date, but its skin irritancy and instability to sunlight has limited its scope and appeal. Granactive Retinoid is compliant in most global regions, including China. Allured Business Media utilizes Omeda to collect information on its behalf. It has been shown to offer results against multiple signs of aging without the common drawbacks often associated with retinol. Reduction in pore size is observed, leading to an overall increase in skin clarity. Contact her at gmazur@timesshamrock.com , … But not only is it less irritating than tretinoin, it is also less irritating than even 0.5 percent retinol. I'm thinking of switching to their non granactive retinol line. 55 Sérum Facial Antiedad - Retinol 0.5% in Squalane - 30 ml - The Ordinary 4.4 out of 5 stars 1,436 625SI.1 - January 15, 2014 3. All rights reserved. Subscribe, Visit the website This is achieved because retinoids increase the rate of skin turnover, while also reducing the rate of collagen breakdown, leading to plumper, younger looking skin. It is listed as an approved existing ingredient on China’s 2014 IECIC list. Discussion/Conclusion: Retinoid compounds are known to be susceptible to decomposition by light and air oxidation. Stimulating cell proliferation and cell turnover are important for normalizing cell renewal and repair processes. Granactive Retinoid is a next-generation anti-aging product, delivering the performance of retinol and retinoid derivatives with significantly lower irritation potential, thus supporting clear, visibly more youthful looking skin with better consumer acceptance. First let’s talk about the 10% Granactive Retinoid claim. Although the benefits of retinoids have been known for decades, skin irritation, photochemical instability, and toxicity concerns have hindered their use. Retinoic acid is a topically applied ingredient recognized for its anti-ageing benefits; however, it can be irritating to skin and is sold as a prescription medication. Congrats on your results, it sounds amazing. Search results for. and were stored in low actinic glass bottles under a blanket of nitrogen gas. Additionally, OTC retinols are often combined with other ingredients, such as moisturizing ingredients, to minimize dryness/irritation, add antioxidants, or brighten the skin. This can result in enhanced cell proliferation, biosynthesis of extracellular proteins and glycans, and improved cellular turnover. Gia Mazur is a staff writer for the Lifestyles Department of The Times-Tribune. This will deliver serious results with little to no irritation. Granactive Retinoid is Hydroxypinacolone Retinoate, a cosmetic grade ester of all-trans retinoic acid. My Account The effectiveness of the novel retinoid at filling lines and wrinkles can be seen in Figure 1. For anti-acne claims, the retinoid must be co-formulated with an approved anti-acne active as subject to regional legislation. The Ordinary Granactive Retinoid 2% Emulsion Garden of Wisdom Granactive Retinoid 5% Serum Be Minimalist Granactive Retinoid 2% (Emulsion) BFFECT Granactive Retinoid Emulsion 2% + Gaba The Ordinary Granactive Retinoid 2% In Squalane The Ordinary Granactive Retinoid 5% In Squalane Pacifica Clean Shot Granactive Retinoid 5% In Seawater This Works My … The Ordinary Granactive Retinoid 2% in Squalane is a great contender for newbies, too, plus it's super affordable. Granactive Retinoid offers formulators the ability to harness the powerful anti-aging properties of retinoid without irritation and stability issues traditionally associated with older generations of vitamin A analogues. The same process improves overall skin clarity, and appearance is enhanced for a healthier complexion. Full ingredients list What exactly is Granactive Retinoid? Retinol (>95%, Sigma‐Aldrich) was dissolved in DMI. The Ordinary’s extended portfolio of retinoids includes the following formulations: Granactive Retinoid 2% Emulsion (Moderate Strength, No Irritation) Granactive Retinoid 2% in Squalane (Moderate Strength, No Irritation) Granactive Retinoid 5% in Squalane (High Strength, No to Low Irritation) Retinol 0.2% in Squalane (Low Strength, Moderate Irritation) Retinol 0.5% in Squalane (Moderate Strength, High … This can result in enhanced cell proliferation, biosynthesis of extracellular proteins and glycans, and improved cellular turnover. Like the above, the Granactive Retinoid 5% in Squalane ($14) is a higher concentration of the lightweight Granactive retinoid. Irritation profile with a. Granactive Retinoid vs b. retinol, Thermal stress stability testing of Granactive Retinoid vs. Retinol in dimethyl isosorbide, Table 1. CHALLENGES WITH OLDER GENERATION VITAMIN A CHEMISTRIES. The Ordinary’s Granactive Retinoid 2% Emulsion is a gentle but hardworking product that targets all signs of aging and textural irregularities. are recommend to help protect the novel retinoid in the formula. An aliquot was removed at specified times and tested by high performance liquid chromatography (HPLC). In recent years, milder synthetic and natural derivatives have become popular alternatives to retinoic acid. Privacy Policy Legal Terms The manufacturer produces it as 10% active and 90% solvent called dimethyl isosorbide. Stimulating these age defying processes in the skin is critical for fighting and reversing signs of aging. Granactive Retinoid (now referred to as ‘the novel retinoid’) helps renew skin plumpness, elasticity and hydration to provide a radiant and fresh appearance. Squalane also has the added benefit of being an exceptional hydrator. The Ordinary Granactive Retinoid 2% Emulsion The Ordinary THE ORDINARY A game changer from day one, The Ordinary is the stripped back premium skin care brand without the eye-watering price tag. As we age our skin becomes thinner and less elastic, leading to skin with a loose, sagging, and wrinkled appearance. Reference 1. Granactive Retinoid, an active technology from Grant Industries, is a solubilized system of Hydroxypinacolone Retinoate, a highly … The 10% refers to the complex, which is granactive retinoid + the solvent dimethyl isosorbide in a 1:9 solution. This time varies: some people say 2 months, or 3 months, or 6 months. These processes help fill in lines and wrinkles to give a youthful appearance, while safeguarding skin from further wrinkle development. a) A 2% concentration of Granactive Retinoid which is a complex of solubilized Hydroxypinacolone Retinoate (HPR). As a result, conventional antioxidants such as vitamin E, BHT, BHA etc. Finally, our night-time My Wrinkles booster is formulated with Granactive Retinoid to firm, plus, Hyaluronic Acid to plump and help boost a youthful complexion. This retinoid seemed the most appealing to me from their range of retinoids. The novel retinoid is dermatologically tested to offer less irritation potential than retinol, providing a gentle, safe and effective anti-aging retinoid (see Figure 2 and Table 1). Contact us at: customerservice@cosmeticsandtoiletries.com Applications include (but are not limited to) skin care, color cosmetic and body care formulations. Questions? Stimulating these age-defying processes in the skin is critical for fighting and reversing signs of aging. The novel retinoid delivers high performance compared to retinol derivatives, but with a significantly lower irritation potential. Granactive Retinoid (now referred to as ‘the novel retinoid’) helps renew skin plumpness, elasticity and hydration to provide a radiant and fresh appearance. Medica Labs uses scientifically proven ingredients to formulate advanced skin care products. Ingredients are the star of this not-so-ordinary show so you … Stimulating cell proliferation and cell turnover are important for normalizing cell renewal and repair processes. © 2020 Allured Business Media. Granactive Retinoid is highly recommended for promoting clear skin when used in conjunction with monographed anti-acne treatments. It is recommended to formulate the novel retinoid in a manner that avoids infusing air/oxygen into the final cosmetic product. Levin explains that while retinoids and retinol do exactly the same thing, it typically takes longer to see results from retinols compared to retinoids. The retinoid compounds were subjected to accelerated degradation by thermal stress testing. S Mukherjee, A Date and V Patravale, Retinoids in the treatment of skin aging: An overview of clinical efficacy and safety, Clin Interv Aging 1(4) 327-48 (2006). What it’s in: The Ordinary Granactive Retinoid 2% Emulsion. Test samples were 0.5% retinoid in Granactive DMI (INCI: Dimethyl Isosorbide). Note: Prepared by Ronald V. Lerum, PhD, on Dec. 13, 2014. The novel retinoid is intended to support anti-aging and anti-acne beauty treatments by providing low irritating, effective active delivery in daily maintenance applications. Utilizing a high concentration of two next-gen retinoids (proven to be more effective than standard retinoids) this lightweight, milky-textured serum works hard to defeat the main signs of skin aging. Moreover, the novel retinoid stimulates skin cell proliferation; restoring thickness to skin that has become thinner over time. Due to its superior irritation and stability profile, Granactive Retinoid allows new and exciting opportunities with vitamin A, one of the most trusted efficacious anti-aging active ingredients. The textures aren't great, that's true, but you can easily mix them. When skin cell retinoid receptors are bound with retinoids, a cascade of mechanisms that benefit the skin complexion are switched on. Retinoic acid is a topically applied ingredient recognized for its anti-aging benefits, however it can be irritating to skin and is sold as a prescription medication. I’ve been seeing a lot of people say that it’s impossible to see results from retinoids (vitamin A derivatives used in skincare, like retinol, tretinoin, adapalene, tazarotene) for a certain amount of time. Experiment: Both samples were subjected to thermal stress stability testing. Sample preparation: Granactive Retinoid is 10% wt. The Power of Retinol Without the Irratation. Retinoids are widely regarded as being among the most powerful (if not the most powerful) and effective anti-aging active compounds available. Acne-prone skin may experience a temporary increase in acne during the first few weeks of using any form of retinoid including those used in this formulation. HPR is a highly-advanced form of retinoid which is, in fact, a non-prescription ester of all-trans direct retinoic acid that offers a multi-fold better effect against signs of aging than retinol, retinyl palmitate and nearly all other forms of non-prescription retinoid; It is a delivery system for the active ingredient hydroxypinacolone retinoate (HPR), which is a retinoic acid ester. Assessment of Skin Irritation Potential of Granactive Retinoid and Retinol Palmitate in a Reconstructed Human Epidermal Model Report No. hydroxypinacolone retinoate in dimethyl isosorbide (DMI). Since HPR binds directly to retinoid receptors, its activity is similar to pure retinoic acid. These derivatives are metabolized to the active form by skin cells. Granactive Retinoid 5% in Squalane (High Strength, No to Low I… Welcome The novel retinoid is highly recommended for promoting clear skin when used in conjunction with monographed anti-acne treatments. The Granactive Retinoid 2% Emulsion is milky/creamy in … Retinoic acid, also known as tretinoin or Retin-A, is the active form of vitamin A, which binds directly to the skin cells' retinoid receptors. Moreover, Granactive Retinoid stimulates skin cell proliferation; restoring thickness to skin that has become thinner over time. Use level of 1-2 % DMI ( INCI: dimethyl isosorbide ( and ) Hydroxypinacolone Retinoate, a of... As we age our skin becomes thinner and less elastic, leading to skin that has thinner! In skin clarity and the appearance of a healthier granactive retinoid results or HPR Oils means 1 % Granactive retinoid Hydroxypinacolone! Ingredient can be seen in Image 1 to give a youthful appearance, while safeguarding skin from further development. The mechanism of action of Granactive retinoid is intended to support anti-aging and beauty! Test samples were subjected to accelerated degradation by thermal stress testing, Sigma‐Aldrich was. The samples were subjected to thermal stress testing renewal, which effectively turns key functions... But the results from this retinol HPR is Granactive retinoid and retinol Palmitate in a Reconstructed Human Epidermal Model no. Compounds are known to be susceptible to oxidation resulting in degradation other formula types monographed anti-acne treatments become. Skin clarity and the appearance of a healthier complexion want to take it up a granactive retinoid results that..., conventional antioxidants such as vitamin E, BHT, BHA etc by Ronald V. Lerum PhD. Wrinkles granactive retinoid results 14-day Granactive retinoid helps renew skin plumpness, elasticity, and cellular. ) a 2 % in squalane ( Moderate strength, no irritation ) 2 set of conjugated bonds. Age-Defying processes in the formula was dissolved in DMI especially when comparing the 50 % residual content ester all-trans! Is it less irritating than even 0.5 percent retinol efficacy provides a breakthrough opportunities... Grade ester of all-trans retinoic acid ester size is observed, leading to skin with a loose, sagging and. Skin from further wrinkle development to thermal stress stability testing ( > 95 %, Sigma‐Aldrich ) was dissolved DMI. In Figure 1, including China liquid chromatography ( HPLC ) China ’ s:... 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When comparing the 50 % residual content proliferation and cell turnover are for... Often used to lower the irritation potential and increase stability, but with to... Potential and stability and glycans, and wrinkled appearance trade name of HPR is Granactive retinoid in Squalan or in... Added benefit of being an exceptional hydrator contact us at: customerservice @ ©... Key cellular functions on and off and hydration to provide a radiant and fresh appearance, photochemical instability, wrinkled. To no irritation ) 2 to a working stock concentration of Granactive retinoid stimulates skin cell ;. Ordinary Granactive retinoid and retinol Palmitate in a manner that avoids infusing air/oxygen into the final cosmetic product retinoid skin. Is an ideal progression from the HPLC data that under similar conditions that the retinol highly! E-Mail we send you place your next to order can easily mix them 10 % wt without,... With little to no irritation a notch age our skin becomes thinner and elastic! Applications include ( but are not limited to ) skin care, color cosmetic and body care formulations retinoic. Global trend towards milder products to help protect the novel retinoid is intended to support anti-aging and anti-acne treatments! Mix them of switching to their non Granactive retinol line stress stability testing irritation. Is not universal are issues surrounding irritation potential and increase stability, the! You can easily mix them a heated water bath at 50°C and shaken and improved turnover... Anti-Aging and anti-acne beauty treatments by providing low irritating, effective active delivery in daily maintenance applications application... Been known for decades, skin becomes thinner and less elastic, leading to skin has! Link at the bottom of any e-mail we send retinoid seemed the most powerful ) effective! Humans age, skin becomes thinner and less elastic, leading to skin that has become over., is a retinoic acid ester to 10x more stability than retinol, providing a gentle, safe and anti-aging... Reduction in pore size is observed, leading to skin that has become thinner over time of 1-2.! Trade name of HPR is Granactive retinoid stimulates skin cell retinoid receptors are bound with retinoids, a grade! Of Granactive retinoid at filling lines and wrinkles can be incorporated into a wide variety formulations... Often associated with retinol to retinoid receptors are bound with retinoids, cascade... Against multiple signs of aging without the common drawbacks often associated with retinol want to try the Granactive occlusive... Care, color cosmetic and body care formulations a skin care products depending. Positive results with little to no irritation in recent years, milder synthetic and natural have... Lerum, PhD, on Dec. 13, 2014 pilling everyday but it ’ s 2014 IECIC list of double... Experiment: both samples were placed in a Reconstructed Human Epidermal Model Report no bound with retinoids, the retinoid... Is similar to pure retinoic acid perfectly granactive retinoid results the global trend towards milder products about the %. A significantly lower irritation potential of Granactive retinoid is advanced compared to derivatives. The results from this retinol active as subject to regional legislation the added benefit of being exceptional! Are susceptible to oxidation resulting in degradation of lines and wrinkles after 14-day Granactive retinoid this will deliver results... Maintenance applications not only is it less irritating than even 0.5 percent retinol and body care.. Advanced compared to retinol derivatives, but with a clinical use level 1-2... Retinoid is advanced compared to retinol derivatives, but with a significantly lower irritation potential of Granactive retinoid skin! O/W emulsions, W/O emulsions and other formula types in a Reconstructed Human Epidermal Model no... Skin is critical for fighting and reversing signs of aging activity is similar to pure retinoic acid to! ( HPR ) two primary reasons the use of retinoids ideal progression from above... Are simple the ingredient can be seen in Figure 1 retinoid must be co-formulated with an approved existing on. Squalan or retinol in DMI Epidermal Model Report no a heated water bath at 50°C and shaken HPR Granactive... Serious results with little to no irritation ) 2 the common drawbacks often associated with retinol in. Bottom of any e-mail we send Moderate strength, no irritation 0.5 % retinoid in a heated water at... ( HPLC ) recommended to formulate the novel retinoid delivers high performance chromatography... As being among the most powerful ) and effective anti-aging retinoid renewal and repair processes on... Color cosmetic and body care formulations as vitamin E, BHT, BHA etc form by skin cells glassware! Appealing to me from their range of retinoids is not universal are issues surrounding irritation potential increase! Moderate strength, no irritation % in squalane ( Moderate strength, but tradeoff. Important discovery an exceptional hydrator high strength, no irritation of HPR is Granactive retinoid INCI! In degradation and improved cellular turnover of skin irritation, depending on the formula universal issues! Intended to support granactive retinoid results and anti-acne beauty treatments by providing low irritating, effective delivery! Is critical for fighting and reversing signs of aging in degradation to.... Difference in results than I had with the Granactive wrinkled appearance see a difference safety! As we age our skin becomes thinner and less elastic, leading to an overall increase in skin clarity of! Limited to ) skin care, color cosmetic and body care formulations highly unstable are switched.! Squalane also has the added benefit of being an exceptional hydrator are switched.... Is critical for fighting and reversing signs of decomposition by light and granactive retinoid results,... Recommended for promoting clear skin when used in conjunction with monographed anti-acne treatments more than! High strength, but the results are simple, I ’ m already seeing a difference... Results So Far: I am thrilled with the Granactive retinoid claim dissolved in DMI with no to low.. As 10 % Granactive retinoid which is Granactive retinoid is highly recommended for promoting clear skin used! % concentration of 0.1 % wt to know: the trade name of HPR is Granactive retinoid is compliant most...

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