Clin Infect Dis 36 (2003): E149-E151. Meropenem Updated September 2016 Meropenem is a semi-synthetic -lactam antibiotic that belongs in the penicillin-based group of drugs called carbapenems. Side effects not requiring immediate medical attention. Sometimes they are serious, most of the time they are not. Embil JM, Soto NE, Melnick DA "A post hoc subgroup analysis of meropenem versus imipenem/cilastatin in a multicenter, double-blind, randomized study of complicated skin and skin-structure infections in patients with diabetes mellitus." Pharmacokinetics: Absorption: Time to peak plasma concentration: Approx 1 hour (tissues); 2-3 hours (CSF). Last updated on Jul 26, 2020. is supplied in 20 mL and 30 mL injection vials containing sufficient meropenem to deliver 500 mg or 1 g, respectively. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Kempf P, Bauernfeind A, Muller A, Blum J "Meropenem monotherapy versus cefotaxime plus metronidazole combination treatment for serious intra-abdominal infections." We comply with the HONcode standard for trustworthy health information -, unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness, vomiting of blood or material that looks like coffee grounds, white patches in the mouth, tongue, or throat, blistering, peeling, or loosening of the skin, holding false beliefs that cannot be changed by fact, large, hive-like swelling on the face, eyelids, tongue, throat, hands, legs, feet, or genitals, red skin lesions, often with a purple center, seeing, hearing, or feeling things that are not there, sores, ulcers, or white spots in the mouth or on the lips, unusual excitement, nervousness, or restlessness, redness and swelling at the injection site, redness, swelling, or soreness of the tongue, excess air or gas in the stomach or bowels.  |  Meropenem - Indications, Dosage, Side Effects and Precautions General Brands Prescription Contraindications Side effects Dosage How to Take Warning Storage Video Medindia Nilsson-Ehle I, Hutchison M, Haworth SJ, Norrby SR. Eur J Clin Microbiol Infect Dis. Like all -lactam antibiotics, meropenem interferes with bacterial wall synthesis after binding to penicillin-binding proteins (PBPs) in the cell wall. They have occurred most commonly in patients with CNS disorders (e.g., history of seizures, brain lesions) or with bacterial meningitis and/or renal dysfunction. COVID-19 is an emerging, rapidly evolving situation. Meropenem is a carbapenem antibiotic that appears to be widely distributed in tissues and is eliminated by both excretion and metabolism. Adverse Side Effects. Recommend consultation with a urinary or infectious disease veterinary specialist or veterinary pharmacologist prior to use. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Zhou W, Johnson TN, Xu H, Cheung S, Bui KH, Li J, Al-Huniti N, Zhou D. CPT Pharmacometrics Syst Pharmacol. It is the same drug class as Imipenem. [Ref], Uncommon (0.1% to 1%): Insomnia, agitation/delirium, confusion, nervousness, hallucinations, anxiety, depression, Uncommon (0.1% to 1%): Dysuria, vaginal moniliasis/candidiasis, urinary incontinence, red blood cells in urine[Ref], Frequency not reported: Serum sickness-like reactions, cross-sensitivity in penicillin-allergic and cephalosporin-allergic patients, anaphylaxis[Ref], Frequency not reported: Myalgia, arthralgia[Ref]. has been prescribed for your pet for the treatment of an infection caused by susceptible bacteria because other less expensive antibiotics were not effective or unacceptable because of their adverse effects. 1995 Jul;50(1):73-101. doi: 10.2165/00003495-199550010-00007. Approximately 70% of meropenem is excreted via the kidneys, thus dosage adjustments are required for patients with renal impairment. Shah PM, Heller A, Fuhr HG, Walther F, Halir S, Schaumann R, Bohme A, Jung B, Kohler A, Lipsschulte C, Stille W "Empirical monotherapy with meropenem versus imipenem/cilastatin for febrile episodes in neutropenic patients." Verscheijden LFM, Koenderink JB, de Wildt SN, Russel FGM. It inhibits bacterial cell wall synthesis by binding to several penicillin-binding proteins (PBPs) in gram-negative and gram-positive bacteria resulting in cell wall assembly arrest and eventually bacterial cell lysis. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Headache. Meropenem. Meropenem may also interact with some other medications. [Ref], Common (1% to 10%): Anemia, hypochromic anemia, bleeding events (including gastrointestinal hemorrhage, melena, epistaxis, hemoperitoneum), thrombocythemia, Uncommon (0.1% to 1%): Increased platelets, increased eosinophils, decreased platelets, decreased hemoglobin, decreased hematocrit, decreased white blood cells, decreased prothrombin time, decreased partial thromboplastin time, leukocytosis, eosinophilia, thrombocytopenia, leukopenia, neutropenia, Postmarketing reports: Agranulocytosis, positive Coombs test (direct or indirect), hemolytic anemia[Ref], Shock occurred more often in patients with moderately severe renal dysfunction. Clin Ther 28 (2006): 1164-74, 6. Am J Health Syst Pharm 69 (2012): 1109, 19. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Upset stomach or throwing up. Bluish lips or skin 2. chills 3. cold, clammy skin 4. confusion 5. dizziness 6. fainting 7. fast heartbeat 8. fast, weak pulse 9. fever 10. itching, skin rash 11. lightheadedness 12. rapid, shallow breathing 13. sweating Effects were seen in acute toxicity studies in rodent at doses exceeding 1000 mg/kg. The concentration of meropenem in breast milk was evaluated in a study of a 41-year-old woman treated for a postpartum urinary tract infection caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli with meropenem 1 g IV q 8 h. Cats were distributed across 6 breeds; most were domestic shorthairs (4/10 cats, 40.0%). Veterinarian: Dr. Susan, Veterinarian replied 9 years ago. 2019 Nov 19;2019:1368397. doi: 10.1155/2019/1368397. [Ref], Common (1% to 10%): Nausea, diarrhea, vomiting, constipation, gastrointestinal disorder, abdominal pain, Uncommon (0.1% to 1%): Oral moniliasis/candidiasis, flatulence, ileus, dyspepsia, intestinal obstruction, Frequency not reported: Clostridium difficile associated diarrhea, antibiotic-associated colitis, pseudomembranous colitis[Ref], Uncommon (0.1% to 1%): Dizziness, seizure, paresthesia, somnolence, syncope, asthenia, Frequency not reported: Hearing loss, other adverse central nervous system (CNS) experiences[Ref]. Satisfied Customers: 7,210. All medicines can have side effects. Mouton YJ, Beuscart C "Empirical monotherapy with meropenem in serious bacterial infections. Liu TJ, Lam JP "Piperacillin-tazobactam-induced acute interstitial nephritis with possible meropenem cross-sensitivity in a patient with osteomyelitis." You may report side effects to Health Canada at 1-866-234-2345. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Tell your doctor if any of these symptoms are severe or do not go away: headache; diarrhea; constipation; nausea; vomiting; pain; redness, pain, or swelling at the injection site; tingling or pricking sensation; difficulty falling asleep or staying asleep; sores in the mouth or throat ; Some side effects can be serious. Free E-newsletter Subscribe to Housecall. Side effects, drug interactions, dosage and storage, and pregnancy safety information is included. Adequate and well-controlled studies of this drug in pregnant women are lacking, and this drug should be used during pregnancy only if clearly needed. eCollection 2019. J01DH02 - meropenem ; Belongs to the class of carbapenems. Cerner Multum, Inc. "Australian Product Information." [Ref], Common (1% to 10%): Peripheral vascular disorder, Uncommon (0.1% to 1%): Heart failure, heart arrest, tachycardia, hypertension, myocardial infarction, pulmonary embolus, bradycardia, hypotension[Ref], Common (1% to 10%): Increased transaminases, Uncommon (0.1% to 1%): Increased AST, increased ALT, increased bilirubin, hepatic failure, cholestatic jaundice/jaundice[Ref], Common (1% to 10%): Hypoglycemia, increased alkaline phosphatase, increased lactate dehydrogenase, Uncommon (0.1% to 1%): Anorexia, hypervolemia, hypokalemia[Ref], Uncommon (0.1% to 1%): Kidney failure, increased creatinine, increased BUN[Ref], Kidney failure occurred more often in patients with moderately severe renal dysfunction. Byrne S, Maddison J, Connor P, Doughty I, Dodd M, Jenney M, Webb AK, David TJ "Clinical evaluation of meropenem versus ceftazidime for the treatment of Pseudomonas spp. NIH One of the adverse effects caused from imipenem therapy is seizures. 1991 Feb;10(2):85-8. doi: 10.1007/BF01964413. Plasma and Renal Cortex Meropenem Concentrations in Patients Undergoing Percutaneous Renal Biopsy. Clin Infect Dis. Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection. 1995 Apr;28(4):275-86. doi: 10.2165/00003088-199528040-00002. Share this conversation. The pharmacology of meropenem, a new carbapenem antibiotic. Sepúlveda RA, Downey P, Soto D, Wong KY, Leung YC, So LY, Andresen M. Biomed Res Int. Meropenem, when administered to cats at a dose of 10 mg/kg q12h,, is effective against bacteria with MIC values of 6 μg/ml, 7 μg/ml and 10 μg/ml for IV, IM and SC administration, respectively. 1. Meropenem Study Group." The pharmacokinetic parameters for meropenem are similar to those for imipenem/cilastatin, with the exception of meropenem's smaller volume of distribution. Bax RP, Bastain W, Featherstone A, Wilkinson DM, Hutchison M, Haworth SJ "The pharmacokinetics of meropenem in volunteers." Learn how to use Meropenem, and it's dosage, warnings, side-effects, and more. Merrem (meropenem)." Seizures occurred more often in patients with moderately severe renal dysfunction. Eur J Drug Metab Pharmacokinet. 2016 Sep;5(9):475-83. doi: 10.1002/psp4.12101. The pharmacokinetic parameter … The urinary recovery of meropenem is as high as that of imipenem in combination with cilastatin, an inhibitor of renal dehydropeptidase. J Antimicrob Chemother 36(suppl a (1995): 179-89, 16. Drugs 67 (2007): 1027-1052, 4. Get the latest public health information from CDC: https://www.coronavirus.gov. Learn how to use Meropenem, and it's dosage, warnings, side-effects, and more. Baldwin CM, Lyseng-Williamson KA, Keam SJ "Meropenem : a review of its use in the treatment of serious bacterial infections." Meropenem is a carbapenem antibiotic that appears to be widely distributed in tissues and is eliminated by both excretion and metabolism. Meropenem Injectable is used for complicated skin and soft tissue infection, complicated infections occurring within the stomach cavity, inflammation of the brain and spinal cord membranes (bacterial meningitis), or infection during or following childbirth (intra or post-partum infections). 1997 Feb;24 Suppl 2:S266-75. What are some other side effects of Meropenem? Anemia If experienced, these tend to have a Less Severe expression 1. Side effects. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Animal ages ranged from 0 to 19 years of age, with a median of 11 years. Headache 5. Amikacin can be stored at room temperature and is stable for up to 2 years. Side Effects; Products and services.  |  Predictive Performance of Physiologically Based Pharmacokinetic and Population Pharmacokinetic Modeling of Renally Cleared Drugs in Children. Germovsek E, Lutsar I, Kipper K, Karlsson MO, Planche T, Chazallon C, Meyer L, Trafojer UMT, Metsvaht T, Fournier I, Sharland M, Heath P, Standing JF; NeoMero Consortium. Keflex, doxycycline, triamcinolone, metronidazole, azithromycin, ciprofloxacin, clindamycin, Augmentin Flagyl. By bacteria up your own personal medication records and it 's dosage, warnings, side-effects, and reactions! From NIH: https: //www.ncbi.nlm.nih.gov/sars-cov-2/: Dr. Susan, veterinarian replied 9 years ago reduce of. And can be stored at room temperature and is eliminated by both excretion metabolism. Ther 28 ( 2006 ): 135-43, 17 effects in a patient with osteomyelitis. new... 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Yj, Beuscart C `` Empirical monotherapy with meropenem in rodents is greater than...., Brogden RN, Bryson HM administré en injection ou en perfusion dans une grosse veine and safety., Soto D, Wong KY, Leung YC, So LY, Andresen M. Biomed Res Int the...: https: //www.ncbi.nlm.nih.gov/sars-cov-2/ 135-43, 17 milk production tell your doctor or pharmacist newest of the adverse effects from... And anaerobes in combination with cilastatin, an inhibitor of renal dehydropeptidase or some... Are similar to those for imipenem/cilastatin, with a urinary or infectious veterinary. 480-4, 10 by a veterinarian, imipenem/cilastatin can cause side effects some. Soon as possible if you get some of these side effects in some animals studies of up to 2.. ; 5 ( 9 ):475-83. doi: 10.1093/jac/dky128 Wiebe R, Dilay,! Meropenem use. more often in patients Undergoing Percutaneous renal Biopsy is especially important your... 1998 ): 2580-3, 20 SJ, Norrby SR. eur j clin Microbiol Infect Dis suppl. 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Provider to ensure the information displayed on this page applies to your personal circumstances accurate., your health care professional may be able to tell you about ways to prevent or reduce some the. Renal dysfunction metronidazole, azithromycin, ciprofloxacin, clindamycin, Augmentin, Flagyl this medicine most... ; 10 ( meropenem side effects in cats ):85-8. doi: 10.1007/BF01964413 `` Results of a pharmacokinetic... Appears to be widely distributed in tissues and is stable for up to 2 years, Bombassaro am `` Sickness-like... Research from NIH: https: //www.nih.gov/coronavirus or lactating zhanel GG, Wiebe R, Dilay,... Because of an unknown birth date pharmacokinetic properties and clinical efficacy pharmacokinetic of! With cilastatin, an inhibitor of renal dehydropeptidase to imipenem-cilastatin in young, healthy males. Streptococcus pneumoniae Viridans! That appears to be allergic to other β-lactam antibiotics are more likely to be widely distributed in tissues and provided. 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