EUCAST clinical MIC breakpoints for meropenem (2015-01-01, v5). A positive direct or indirect Coombs test may develop during treatment with meropenem. As necessary, expert advice should be sought when the local prevalence of resistance is such that the utility of the agent in at least some types of infections is questionable. SCHEDULE: SCHEDULE 'H1' DRUG; It is dangerous to take this preparation except in accordance with the medical advice. This information is intended for use by health professionals, Meropenem 1 g powder for solution for injection or infusion. Lung and bronchial infections in patients suffering from cystic fibrosis. The medicinal product is supplied in pack sizes of 1 or 10 vials. A study of 12 patients administered meropenem 1000 mg 8 hourly post-surgically for intra-abdominal infections showed a comparable Cmax and half-life to normal subjects but a greater volume of distribution 27 l. The average plasma protein binding of meropenem was approximately 2 % and was independent of concentration. b) Each Tablet Contains: Sirolimus 1mg Excipients q.s. Reconstituted solution of meropenem in 5% glucose (dextrose) solution should be used immediately, i.e. You may need urgent medical treatment. Merokem 1 gm Injection is safe to use in patients with liver disease. It is preferable to avoid the use of meropenem during pregnancy. MERO PALM. After infusion over 5 minutes Cmax values are 52 and 112 μg/ml after 500 and 1000 mg doses respectively. Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter spp resistance. For intravenous infusion meropenem vial may be directly constituted with 0.9% sodium chloride or 5% glucose (dextrose) solutions for infusion. Isolates may be reported as R without prior testing. When suggestions are available use up and down arrows to review and ENTER to select. Meropenem is indicated for the treatment of the following infections in adults and children aged 3 months and older (see sections 4.4 and 5.1): Treatment of patients with bacteraemia that occurs in association with, or is suspected to be associated with, any of the infections listed above. It should be used with caution in patients with central nervous system disorders. No dose adjustment is required for the elderly with normal renal function or creatinine clearance values above 50 ml/min. Pharmacokinetic studies in healthy elderly subjects (65-80 years) have shown a reduction in plasma clearance, which correlated with age-associated reduction in creatinine clearance, and a smaller reduction in non-renal clearance. Like all medicines, this medicine can cause side effects, although not everybody gets them. Each vial contains meropenem trihydrate equivalent to 500 mg anhydrous meropenem. Monte Carlo simulation based on a population PK model showed that a dose regimen of 20 mg/kg 8 hourly achieved 60 %T>MIC for P. aeruginosa in 95 % of pre-term and 91 % of full term neonates. Meropenem exerts its bactericidal activity by inhibiting bacterial cell wall synthesis in Gram-positive and Gram-negative bacteria through binding to penicillin-binding proteins (PBPs). If not used immediately in-use storage times and conditions are the responsibility of the user. It works by killing bacteria, which can cause serious infections. Enterobacteriaceae Pseudomonas aeruginosa or Acinetobacter spp.) Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter spp resistance. It … Infection affecting the lungs (pneumonia). We have a well-equipped Quality Control (QC) laboratory, which ensures that our products are pure, safe and effective and are released only after thorough analysis as per stringent procedures. The recommended dose regimens are shown in the table below: There is no experience in children with renal impairment. If you get any side effects, talk to your doctor or nurse. Limited human data suggests that the drug does not represent any significant risk to the baby. Caution is required if probenecid is co-administered with meropenem. There is no experience in children with renal impairment. Meropenem is primarily excreted unchanged by the kidneys; approximately 70 % (50 –75 %) of the dose is excreted unchanged within 12 hours. Small amounts of meropenem have been reported to be excreted in human milk. Probenecid competes with meropenem for active tubular secretion and thus inhibits the renal excretion of meropenem with the effect of increasing the elimination half-life and plasma concentration of meropenem. The medicinal product is supplied in pack sizes of 1 or 10 vials. 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